GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs9473555 | 1 | rs60982898 | chr6:49385806 | MUT | chr6:49398994-49431031:- | 0.27 | 4.32 | 3.89E-5 | Folate pathway vitamin levels |
| THYM | cis | rs4237643 | 1 | rs61037750 | chr11:43681372 | HSD17B12 | chr11:43702143-43878160:+ | -0.6 | -5.98 | 3.95E-8 | Forced vital capacity |
| THYM | cis | rs3820928 | 1 | rs61067328 | chr2:227761256 | RHBDD1 | chr2:227700773-227861591:+ | -0.33 | -4.97 | 3.01E-6 | Pulmonary function |
| THYM | cis | rs2275426 | 1 | rs61102033 | chr1:46382441 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -6 | 3.55E-8 | Body mass index |
| THYM | cis | rs911119 | 1 | rs6114206 | chr20:23611789 | CST9 | chr20:23583049-23586610:- | -0.51 | -4.73 | 7.71E-6 | Chronic kidney disease |
| THYM | cis | rs911119 | 1 | rs6114208 | chr20:23621734 | CST9 | chr20:23583049-23586610:- | -0.48 | -4.49 | 2.03E-5 | Chronic kidney disease |
| THYM | cis | rs911119 | 1 | rs6114209 | chr20:23622266 | CST9 | chr20:23583049-23586610:- | -0.49 | -4.44 | 2.39E-5 | Chronic kidney disease |
| THYM | cis | rs6911965 | 1 | rs61280878 | chr6:24468741 | GPLD1 | chr6:24428405-24489850:- | 0.45 | 4.67 | 9.97E-6 | Hematological and biochemical traits |
| THYM | cis | rs6151429 | 1 | rs6151429 | chr22:51063477 | ARSA | chr22:51063450-51066607:- | -0.96 | -6.33 | 8.09E-9 | Blood metabolite levels |
| THYM | cis | rs12780845 | 1 | rs61517255 | chr10:17208918 | CUBN | chr10:16865966-17171816:- | 0.3 | 4.68 | 9.61E-6 | Homocysteine levels |
| THYM | cis | rs61524473 | 1 | rs61524473 | chr15:45646283 | SPATA5L1 | chr15:45694519-45713614:+ | 0.41 | 4.68 | 9.47E-6 | Metabolite levels (small molecules and protein measures) |
| THYM | cis | rs9815354 | 1 | rs61744385 | chr3:41756986 | ULK4 | chr3:41288091-42003660:- | 0.96 | 9.94 | 2.21E-16 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs61744388 | chr3:41756965 | ULK4 | chr3:41288091-42003660:- | 0.96 | 9.94 | 2.21E-16 | Diastolic blood pressure |
| THYM | cis | rs2275426 | 1 | rs61783200 | chr1:46297403 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -5.85 | 6.8E-8 | Body mass index |
| THYM | cis | rs2275426 | 1 | rs61783220 | chr1:46335312 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -5.85 | 6.8E-8 | Body mass index |